I haven't had any problems reading this book even though it's the latest in a series that I haven't read any book in previous. Sure there is history between the characters, stuff they talk about that happened in the previous books, but I never really feel lost in the story.
I'm actually amazed that I have completely missed reading books by Brad Meltzer since I love adventure books. This reminds me that I need to check up his books on amazon...;)